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Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes

Mammalian oocytes spend most of their life in a unique state of cell cycle arrest at meiotic prophase I, during which time they are exposed to countless DNA-damaging events. Recent studies have shown that DNA double-strand break repair occurs predominantly via the homologous recombination (HR) pathw...

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Detalles Bibliográficos
Autores principales: Cai, Xuebi, Stringer, Jessica M., Zerafa, Nadeen, Carroll, John, Hutt, Karla J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322932/
https://www.ncbi.nlm.nih.gov/pubmed/37407587
http://dx.doi.org/10.1038/s41419-023-05886-x