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Modular synthesis of clickable peptides via late-stage maleimidation on C(7)-H tryptophan

Cyclic peptides have attracted tremendous attention in the pharmaceutical industry owing to their excellent cell penetrability, stability, thermostability, and drug-like properties. However, the currently available facile methodologies for creating such peptides are rather limited. Herein, we report...

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Detalles Bibliográficos
Autores principales: Wang, Peng, Liu, Jiang, Zhu, Xiaomei, Kenry, Yan, Zhengqing, Yan, Jiahui, Jiang, Jitong, Fu, Manlin, Ge, Jingyan, Zhu, Qing, Zheng, Yuguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322970/
https://www.ncbi.nlm.nih.gov/pubmed/37407547
http://dx.doi.org/10.1038/s41467-023-39703-y