Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein

Regulation of α-synuclein (αS) fibril formation is a potent therapeutic strategy for αS-related neurodegenerative disorders. αS, an intrinsically disordered 140-residue intraneural protein, comprises positively charged N-terminal, hydrophobic non-amyloid β component (NAC), and negatively charged C-t...

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Detalles Bibliográficos
Autores principales: Ohgita, Takashi, Kono, Hiroki, Morita, Izumi, Oyama, Hiroyuki, Shimanouchi, Toshinori, Kobayashi, Norihiro, Saito, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322983/
https://www.ncbi.nlm.nih.gov/pubmed/37407638
http://dx.doi.org/10.1038/s41598-023-38070-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322983/
https://www.ncbi.nlm.nih.gov/pubmed/37407638
http://dx.doi.org/10.1038/s41598-023-38070-4

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