Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation

Alzheimer’s disease (AD) is characterized by misfolding, oligomerization, and accumulation of amyloid-β (Aβ) peptides in the brain. Aβ monomers transform into Aβ oligomers, which are toxic species, inducing tau hyperphosphorylation and the downstream effects on microglia and astrocytes, triggering s...

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Detalles Bibliográficos
Autores principales: Lee, Donghee, Ryoo, Ji Eun, Hong, Seungpyo, Kim, Hye Yun, Kim, YoungSoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323003/
https://www.ncbi.nlm.nih.gov/pubmed/37407605
http://dx.doi.org/10.1038/s41598-023-36167-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323003/
https://www.ncbi.nlm.nih.gov/pubmed/37407605
http://dx.doi.org/10.1038/s41598-023-36167-4

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