Cargando…

Defining developmental trajectories of prosensory cells in human inner ear organoids at single-cell resolution

The inner ear sensory epithelia contain mechanosensitive hair cells and supporting cells. Both cell types arise from SOX2-expressing prosensory cells, but the mechanisms underlying the diversification of these cell lineages remain unclear. To determine the transcriptional trajectory of prosensory ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ueda, Yoshitomo, Nakamura, Takashi, Nie, Jing, Solivais, Alexander J., Hoffman, John R., Daye, Becca J., Hashino, Eri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2023
Materias:	Human Development
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323240/ https://www.ncbi.nlm.nih.gov/pubmed/37381908 http://dx.doi.org/10.1242/dev.201071

Ejemplares similares

CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids
por: Nie, Jing, et al.
Publicado: (2022)

The Prosensory Function of Sox2 in the Chicken Inner Ear Relies on the Direct Regulation of Atoh1
por: Neves, Joana, et al.
Publicado: (2012)

Deafness-in-a-dish: modeling hereditary deafness with inner ear organoids
por: Romano, Daniel R., et al.
Publicado: (2021)

Generation of inner ear organoids with functional hair cells from human pluripotent stem cells
por: Koehler, Karl R., et al.
Publicado: (2017)

Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids
por: Tang, Pei-Ciao, et al.
Publicado: (2019)

Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells
por: Kumar, Santhosh V., et al.
Publicado: (2019)

Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling
por: Jansen, Jitske, et al.
Publicado: (2022)

Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain
por: Birtele, Marcella, et al.
Publicado: (2022)

Transplanted human intestinal organoids: a resource for modeling human intestinal development
por: Singh, Akaljot, et al.
Publicado: (2023)

Epithelial dynamics shed light on the mechanisms underlying ear canal defects
por: Fons, Juan M., et al.
Publicado: (2020)

Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture
por: DeJonge, Rachel E., et al.
Publicado: (2016)

Human prostate organoid generation and the identification of prostate development drivers using inductive rodent tissues
por: Singh, Parmveer, et al.
Publicado: (2023)

Human iPSC-derived cerebral organoids model features of Leigh syndrome and reveal abnormal corticogenesis
por: Romero-Morales, Alejandra I., et al.
Publicado: (2022)

Progress in Modeling and Targeting Inner Ear Disorders with Pluripotent Stem Cells
por: Tang, Pei-Ciao, et al.
Publicado: (2020)

16p11.2 deletion accelerates subpallial maturation and increases variability in human iPSC-derived ventral telencephalic organoids
por: Fetit, Rana, et al.
Publicado: (2023)

Open chromatin dynamics in prosensory cells of the embryonic mouse cochlea
por: Wilkerson, Brent A., et al.
Publicado: (2019)

Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney
por: Menon, Rajasree, et al.
Publicado: (2018)

BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium
por: Gambardella, Laure, et al.
Publicado: (2019)

RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells
por: Liu, Shuyu, et al.
Publicado: (2023)

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells
por: Giacomelli, Elisa, et al.
Publicado: (2017)

Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture
por: Repina, Nicole A., et al.
Publicado: (2023)

Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture
por: Koehler, Karl R., et al.
Publicado: (2013)

Neural differentiation, selection and transcriptomic profiling of human neuromesodermal progenitor-like cells in vitro
por: Verrier, Laure, et al.
Publicado: (2018)

Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells
por: Nakajima, Taiki, et al.
Publicado: (2018)

In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development
por: Tsai, Yu-Hwai, et al.
Publicado: (2017)

An integrated atlas of human placental development delineates essential regulators of trophoblast stem cells
por: Chen, Yutong, et al.
Publicado: (2022)

PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration
por: Chang, Wen-Lin, et al.
Publicado: (2018)

Integrin α2 marks a niche of trophoblast progenitor cells in first trimester human placenta
por: Lee, Cheryl Q. E., et al.
Publicado: (2018)

Human neural progenitors establish a diffusion barrier in the endoplasmic reticulum membrane during cell division
por: bin Imtiaz, Muhammad Khadeesh, et al.
Publicado: (2022)

Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells
por: Ogura, Takenori, et al.
Publicado: (2018)

Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development
por: Boroviak, Thorsten, et al.
Publicado: (2018)

The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells
por: Barter, Matt J., et al.
Publicado: (2017)

Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast
por: Stirparo, Giuliano G., et al.
Publicado: (2018)

Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features
por: Rayon, Teresa, et al.
Publicado: (2021)

Light-focusing human micro-lenses generated from pluripotent stem cells model lens development and drug-induced cataract in vitro
por: Murphy, Patricia, et al.
Publicado: (2018)

LncRNA HBL1 is required for genome-wide PRC2 occupancy and function in cardiogenesis from human pluripotent stem cells
por: Liu, Juli, et al.
Publicado: (2021)

Unraveling transcriptome dynamics in human spermatogenesis
por: Jan, Sabrina Z., et al.
Publicado: (2017)

A stepwise model of reaction-diffusion and positional information governs self-organized human peri-gastrulation-like patterning
por: Tewary, Mukul, et al.
Publicado: (2017)

Wnt inhibition promotes vascular specification of embryonic cardiac progenitors
por: Reichman, David E., et al.
Publicado: (2018)

Distinct prophase arrest mechanisms in human male meiosis
por: Jan, Sabrina Z., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2hct582b0rnfilirsasv0nnht6