CES1‐Triggered Liver‐Specific Cargo Release of CRISPR/Cas9 Elements by Cationic Triadic Copolymeric Nanoparticles Targeting Gene Editing of PCSK9 for Hyperlipidemia Amelioration

The broad application of clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 genome editing tools is hindered by challenges in the efficient delivery of its two components into specific cells and intracytoplasmic release. Herein, a novel copolymer for delivery of Cas9‐mRNA/ single...

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Detalles Bibliográficos
Autores principales: Zhao, Yunfei, Li, Yun, Wang, Fan, Gan, Xuelan, Zheng, Tianye, Chen, Mengyue, Wei, Li, Chen, Jun, Yu, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323666/
https://www.ncbi.nlm.nih.gov/pubmed/37083231
http://dx.doi.org/10.1002/advs.202300502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323666/
https://www.ncbi.nlm.nih.gov/pubmed/37083231
http://dx.doi.org/10.1002/advs.202300502

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