Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice

INTRODUCTION: Extracellular vesicles (EVs) released by human-induced pluripotent stem cell (hiPSC)-derived neural stem cells (NSCs) have robust antiinflammatory and neurogenic properties due to therapeutic miRNAs and proteins in their cargo. Hence, hiPSC-NSC-EVs are potentially an excellent biologic...

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Detalles Bibliográficos
Autores principales: Attaluri, Sahithi, Jaimes Gonzalez, Jenny, Kirmani, Maha, Vogel, Andrew D., Upadhya, Raghavendra, Kodali, Maheedhar, Madhu, Leelavathi N., Rao, Shama, Shuai, Bing, Babu, Roshni S., Huard, Charles, Shetty, Ashok K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323752/
https://www.ncbi.nlm.nih.gov/pubmed/37424631
http://dx.doi.org/10.3389/fnagi.2023.1200445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323752/
https://www.ncbi.nlm.nih.gov/pubmed/37424631
http://dx.doi.org/10.3389/fnagi.2023.1200445

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