Cargando…

Targeted therapy of advanced parathyroid carcinoma guided by genomic and transcriptomic profiling

Parathyroid carcinoma (PC) is an ultra‐rare malignancy with a high risk of recurrence after surgery. Tumour‐directed systemic treatments for PC are not established. We used whole‐genome and RNA sequencing in four patients with advanced PC to identify molecular alterations that could guide clinical m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teleanu, Maria‐Veronica, Fuss, Carmina T., Paramasivam, Nagarajan, Pirmann, Sebastian, Mock, Andreas, Terkamp, Christoph, Kircher, Stefan, Landwehr, Laura‐Sophie, Lenschow, Christina, Schlegel, Nicolas, Stenzinger, Albrecht, Jahn, Arne, Fassnacht, Martin, Glimm, Hanno, Hübschmann, Daniel, Fröhling, Stefan, Kroiss, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323885/ https://www.ncbi.nlm.nih.gov/pubmed/36808802 http://dx.doi.org/10.1002/1878-0261.13398

Ejemplares similares

Case Report: Abdominal Lymph Node Metastases of Parathyroid Carcinoma: Diagnostic Workup, Molecular Diagnosis, and Clinical Management
por: Lenschow, Christina, et al.
Publicado: (2021)

Detection of Structural Variants in Circulating Cell-Free DNA from Sarcoma Patients Using Next Generation Sequencing
por: Mc Connell, Lauren, et al.
Publicado: (2020)

Ruxolitinib is effective in the treatment of a patient with refractory T‐ALL
por: Jaramillo, Sonia, et al.
Publicado: (2020)

Evaluation of diagnostic efficacy for localization of parathyroid adenoma in patients with primary hyperparathyroidism undergoing repeat surgery
por: Hendricks, Anne, et al.
Publicado: (2021)

Community-driven development of a modified progression-free survival ratio for precision oncology
por: Mock, Andreas, et al.
Publicado: (2019)

Integrating next-generation sequencing into clinical oncology: strategies, promises and pitfalls
por: Horak, Peter, et al.
Publicado: (2016)

The landscape of chromothripsis across adult cancer types
por: Voronina, Natalia, et al.
Publicado: (2020)

Impact of the Chemokine Receptors CXCR4 and CXCR7 on Clinical Outcome in Adrenocortical Carcinoma
por: Chifu, Irina, et al.
Publicado: (2020)

Correction to: Deconvolution of sarcoma methylomes reveals varying degrees of immune cell infiltrates with association to genomic aberrations
por: Simon, Malte, et al.
Publicado: (2022)

Deconvolution of sarcoma methylomes reveals varying degrees of immune cell infiltrates with association to genomic aberrations
por: Simon, Malte, et al.
Publicado: (2021)

Reassessment of Postural Stimulation Testing as a Simple Tool to Identify a Subgroup of Patients With Unilateral Primary Aldosteronism
por: Teresa Fuss, Carmina, et al.
Publicado: (2021)

Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity
por: Möhrmann, Lino, et al.
Publicado: (2022)

NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology
por: Mock, Andreas, et al.
Publicado: (2023)

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification
por: Gröschel, Stefan, et al.
Publicado: (2016)

Expression of the Chemokine Receptor CCR7 in the Normal Adrenal Gland and Adrenal Tumors and Its Correlation with Clinical Outcome in Adrenocortical Carcinoma
por: Fuss, Carmina Teresa, et al.
Publicado: (2021)

Epithelial and Mesenchymal Markers in Adrenocortical Tissues: How Mesenchymal Are Adrenocortical Tissues?
por: Sbiera, Iuliu, et al.
Publicado: (2021)

Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance
por: Horak, Peter, et al.
Publicado: (2019)

Confirmatory testing of primary aldosteronism with saline infusion test and LC-MS/MS
por: Fuss, Carmina Teresa, et al.
Publicado: (2020)

Successful BRAF/MEK inhibition in a patient with BRAF(V600E)-mutated extrapancreatic acinar cell carcinoma
por: Busch, Elena, et al.
Publicado: (2020)

Prolonged Survival of a Patient with Advanced-Stage Combined Hepatocellular-Cholangiocarcinoma
por: Loosen, Sven H., et al.
Publicado: (2020)

Feasibility and outcome of reproducible clinical interpretation of high-dimensional molecular data: a comparison of two molecular tumor boards
por: Rieke, Damian T., et al.
Publicado: (2022)

Rationale and design of the CRAFT (Continuous ReAssessment with Flexible ExTension in Rare Malignancies) multicenter phase II trial
por: Heilig, C.E., et al.
Publicado: (2021)

From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards
por: Perera-Bel, Júlia, et al.
Publicado: (2018)

Role of FGF Receptors and Their Pathways in Adrenocortical Tumors and Possible Therapeutic Implications
por: Sbiera, Iuliu, et al.
Publicado: (2021)

Interplay between glucocorticoids and tumor-infiltrating lymphocytes on the prognosis of adrenocortical carcinoma
por: Landwehr, Laura-Sophie, et al.
Publicado: (2020)

Transcriptome profiling for precision cancer medicine using shallow nanopore cDNA sequencing
por: Mock, Andreas, et al.
Publicado: (2023)

Knowledge bases and software support for variant interpretation in precision oncology
por: Borchert, Florian, et al.
Publicado: (2021)

Knowledge bases and software support for variant interpretation in precision oncology
por: Borchert, Florian, et al.
Publicado: (2021)

Accurate and efficient detection of gene fusions from RNA sequencing data
por: Uhrig, Sebastian, et al.
Publicado: (2021)

Definition and diagnosis of postsurgical hypoparathyroidism after thyroid surgery: meta-analysis
por: Nagel, Kathrin, et al.
Publicado: (2022)

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
por: Gröschel, Stefan, et al.
Publicado: (2019)

Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer
por: Giessler, Klara M., et al.
Publicado: (2017)

Questionable value of [(99m)Tc]-sestamibi scintigraphy in patients with pHPT and negative ultrasound
por: Lenschow, Christina, et al.
Publicado: (2022)

Targeted Gene Expression Profile Reveals CDK4 as Therapeutic Target for Selected Patients With Adrenocortical Carcinoma
por: Liang, Raimunde, et al.
Publicado: (2020)

MON-525 Cardiovascular Status in Chronic Hypoparathyroidism: A Prospective Single-Center Analysis in 143 Patients
por: Fuss, Carmina, et al.
Publicado: (2019)

Accurate tumor purity determination is critical for the analysis of homologous recombination deficiency (HRD)
por: Menzel, Michael, et al.
Publicado: (2023)

Many Roads Lead to snoRNAs: The Ever-Expanding Universe of Non-Coding RNAs in Acute Myeloid Leukemia
por: Fröhling, Stefan
Publicado: (2017)

TelomereHunter – in silico estimation of telomere content and composition from cancer genomes
por: Feuerbach, Lars, et al.
Publicado: (2019)

Giant Parathyroid Tumor: Parathyroid Adenoma versus Parathyroid Carcinoma
por: Gossili, Farid, et al.
Publicado: (2022)

Integrative genomic and transcriptomic analysis of leiomyosarcoma
por: Chudasama, Priya, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gkq3gl7dt3untbg6ckss0glikl