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DNA-Compatible Conditions for the Formation of N-Methyl Peptide Bonds

[Image: see text] DNA-encoded libraries (DELs) are a powerful platform in drug discovery. Peptides have unique properties that make them attractive pharmaceutical candidates. N-methylation of the peptide backbone can confer beneficial properties such as increased proteolytic stability and membrane p...

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Detalles Bibliográficos
Autores principales: Zhang, Panpan, Koch, Grant, Zhang, Yankun, Yang, Kevin, Lokey, R. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323948/
https://www.ncbi.nlm.nih.gov/pubmed/37426286
http://dx.doi.org/10.1021/acsomega.3c00576