Novel Pyrano[3,2-c]quinoline-1,2,3-triazole Hybrids as Potential Anti-Diabetic Agents: In Vitro α-Glucosidase Inhibition, Kinetic, and Molecular Dynamics Simulation

[Image: see text] In this study, a novel series of pyrano[3,2-c]quinoline-1,2,3-triazole hybrids 8a–o were synthesized and evaluated against the α-glucosidase enzyme. All compounds showed significant in vitro inhibitory activity (IC(50) values of 1.19 ± 0.05 to 20.01 ± 0.02 μM) compared to the stand...

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Detalles Bibliográficos
Autores principales: Esmaili, Soheila, Ebadi, Ahmad, Khazaei, Ardeshir, Ghorbani, Hamideh, Faramarzi, Mohammad Ali, Mojtabavi, Somayeh, Mahdavi, Mohammad, Najafi, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324058/
https://www.ncbi.nlm.nih.gov/pubmed/37426262
http://dx.doi.org/10.1021/acsomega.3c00133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324058/
https://www.ncbi.nlm.nih.gov/pubmed/37426262
http://dx.doi.org/10.1021/acsomega.3c00133

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