Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1

BACKGROUND: Following solid organ transplantation, tacrolimus (TAC) is an essential drug in the immunosuppressive strategy. Its use constitutes a challenge due to its narrow therapeutic index and its high inter- and intra-pharmacokinetic (PK) variability. As the contribution of the gut microbiota to...

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Detalles Bibliográficos
Autores principales: Degraeve, Alexandra L., Haufroid, Vincent, Loriot, Axelle, Gatto, Laurent, Andries, Vanessa, Vereecke, Lars, Elens, Laure, Bindels, Laure B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324113/
https://www.ncbi.nlm.nih.gov/pubmed/37408070
http://dx.doi.org/10.1186/s40168-023-01578-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324113/
https://www.ncbi.nlm.nih.gov/pubmed/37408070
http://dx.doi.org/10.1186/s40168-023-01578-y

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