The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

BACKGROUND: Previous studies show that antibiotic-mediated (abx) alteration of the gut microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory microglial phenotype in male APPPS1-21 mice. However, the effect of GMB perturbation on astrocyte phenotypes and microglial-...

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Detalles Bibliográficos
Autores principales: Chandra, Sidhanth, Di Meco, Antonio, Dodiya, Hemraj B., Popovic, Jelena, Cuddy, Leah K., Weigle, Ian Q., Zhang, Xiaoqiong, Sadleir, Katherine, Sisodia, Sangram S., Vassar, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324210/
https://www.ncbi.nlm.nih.gov/pubmed/37415149
http://dx.doi.org/10.1186/s13024-023-00635-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324210/
https://www.ncbi.nlm.nih.gov/pubmed/37415149
http://dx.doi.org/10.1186/s13024-023-00635-2

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