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The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

BACKGROUND: Previous studies show that antibiotic-mediated (abx) alteration of the gut microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory microglial phenotype in male APPPS1-21 mice. However, the effect of GMB perturbation on astrocyte phenotypes and microglial-...

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Detalles Bibliográficos
Autores principales:	Chandra, Sidhanth, Di Meco, Antonio, Dodiya, Hemraj B., Popovic, Jelena, Cuddy, Leah K., Weigle, Ian Q., Zhang, Xiaoqiong, Sadleir, Katherine, Sisodia, Sangram S., Vassar, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324210/ https://www.ncbi.nlm.nih.gov/pubmed/37415149 http://dx.doi.org/10.1186/s13024-023-00635-2

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