Inhibition of mammalian target of rapamycin complex 1 in the brain microvascular endothelium ameliorates diabetic Aβ brain deposition and cognitive impairment via the sterol‐regulatory element‐binding protein 1/lipoprotein receptor‐associated protein 1 signaling pathway

AIMS: Mammalian target of rapamycin complex 1 (mTORC1) is highly activated in diabetes, and the decrease of low‐density lipoprotein receptor‐associated protein 1 (LRP1) in brain microvascular endothelial cells (BMECs) is a key factor leading to amyloid‐β (Aβ) deposition in the brain and diabetic cog...

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Detalles Bibliográficos
Autores principales: Jiang, Gege, Long, Zhenzhen, Wang, Yaoling, Wang, Yaofeng, Xue, Ping, Chen, Minfang, Yang, Kang, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324353/
https://www.ncbi.nlm.nih.gov/pubmed/36890627
http://dx.doi.org/10.1111/cns.14133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324353/
https://www.ncbi.nlm.nih.gov/pubmed/36890627
http://dx.doi.org/10.1111/cns.14133

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