Enabling Peptide Ligation at Aromatic Junction Mimics via Native Chemical Ligation and Palladium-Mediated S-Arylation

[Image: see text] Synthetic strategies to assemble peptide fragments are in high demand to access homogeneous proteins for various applications. Here, we combined native chemical ligation (NCL) and Pd-mediated Cys arylation to enable practical peptide ligation at aromatic junctions. The utility of o...

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Detalles Bibliográficos
Autores principales: Lin, Xiaoxi, Nithun, Raj V., Samanta, Raju, Harel, Omer, Jbara, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324392/
https://www.ncbi.nlm.nih.gov/pubmed/37318270
http://dx.doi.org/10.1021/acs.orglett.3c01652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324392/
https://www.ncbi.nlm.nih.gov/pubmed/37318270
http://dx.doi.org/10.1021/acs.orglett.3c01652

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