TBK1 Knockdown Alleviates Axonal Transport Deficits in Retinal Ganglion Cells Via mTORC1 Activation in a Retinal Damage Mouse Model

PURPOSE: Glaucoma is the leading cause of irreversible blindness worldwide and is characterized by progressive retinal ganglion cell (RGC) death and optic nerve degeneration. Axonal transport deficits are the earliest crucial pathophysiological changes in glaucoma. Genetic variation in the TANK-bind...

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Detalles Bibliográficos
Autores principales: Ye, Meng, Hu, Yuanyuan, Zhao, Bowen, Mou, Qianxue, Ni, Yueqi, Luo, Jing, Li, Lu, Zhang, Hong, Zhao, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Glaucoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324417/
https://www.ncbi.nlm.nih.gov/pubmed/37395713
http://dx.doi.org/10.1167/iovs.64.10.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324417/
https://www.ncbi.nlm.nih.gov/pubmed/37395713
http://dx.doi.org/10.1167/iovs.64.10.1

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