Novel pyrimidine Schiff bases and their selenium-containing nanoparticles as dual inhibitors of CDK1 and tubulin polymerase: design, synthesis, anti-proliferative evaluation, and molecular modelling

Nanotechnology-based strategies can overcome the limitations of conventional cancer therapies. Hence, novel series of pyrimidine Schiff bases (4–9) were employed in the synthesis of selenium nanoparticle forms (4NPs–9NPs). All selenium nano-sized forms exerted greater inhibitions than normal-sized c...

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Detalles Bibliográficos
Autores principales: El-Kalyoubi, Samar, El-Sebaey, Samiha A., El-Sayed, Ahmed A., Abdelhamid, Moustafa S., Agili, Fatimah, Elfeky, Sherin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324454/
https://www.ncbi.nlm.nih.gov/pubmed/37403517
http://dx.doi.org/10.1080/14756366.2023.2232125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324454/
https://www.ncbi.nlm.nih.gov/pubmed/37403517
http://dx.doi.org/10.1080/14756366.2023.2232125

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