Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters

The pediatric live-attenuated bovine/human parainfluenza virus type 3 (B/HPIV3)-vectored vaccine expressing the prefusion-stabilized SARS-CoV-2 spike (S) protein (B/HPIV3/S-2P) was previously evaluated in vitro and in hamsters. To improve its immunogenicity, we generated B/HPIV3/S-6P, expressing S f...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xueqiao, Park, Hong-Su, Matsuoka, Yumiko, Santos, Celia, Yang, Lijuan, Luongo, Cindy, Moore, Ian N., Johnson, Reed F., Garza, Nicole L., Zhang, Peng, Lusso, Paolo, Best, Sonja M., Buchholz, Ursula J., Le Nouën, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325082/
https://www.ncbi.nlm.nih.gov/pubmed/37352333
http://dx.doi.org/10.1371/journal.ppat.1011057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325082/
https://www.ncbi.nlm.nih.gov/pubmed/37352333
http://dx.doi.org/10.1371/journal.ppat.1011057

Ejemplares similares