The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression

Identification of host determinants of coronavirus infection informs mechanisms of pathogenesis and may provide novel therapeutic targets. Here, we demonstrate that the histone demethylase KDM6A promotes infection of diverse coronaviruses, including SARS-CoV, SARS-CoV-2, MERS-CoV and mouse hepatitis...

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Detalles Bibliográficos
Autores principales: Wei, Jin, Alfajaro, Mia Madel, Cai, Wesley L., Graziano, Vincent R., Strine, Madison S., Filler, Renata B., Biering, Scott B., Sarnik, Sylvia A., Patel, Sonam, Menasche, Bridget L., Compton, Susan R., Konermann, Silvana, Hsu, Patrick D., Orchard, Robert C., Yan, Qin, Wilen, Craig B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325096/
https://www.ncbi.nlm.nih.gov/pubmed/37410700
http://dx.doi.org/10.1371/journal.ppat.1011351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325096/
https://www.ncbi.nlm.nih.gov/pubmed/37410700
http://dx.doi.org/10.1371/journal.ppat.1011351

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