α(1)-Adrenergic receptor–PKC–Pyk2–Src signaling boosts L-type Ca(2+) channel Ca(V)1.2 activity and long-term potentiation in rodents

The cellular mechanisms mediating norepinephrine (NE) functions in brain to result in behaviors are unknown. We identified the L-type Ca(2+) channel (LTCC) Ca(V)1.2 as a principal target for G(q)-coupled α(1)-adrenergic receptors (ARs). α(1)AR signaling increased LTCC activity in hippocampal neurons...

Descripción completa

Detalles Bibliográficos
Autores principales: Man, Kwun Nok Mimi, Bartels, Peter, Henderson, Peter B, Kim, Karam, Shi, Mei, Zhang, Mingxu, Ho, Sheng-Yang, Nieves-Cintron, Madeline, Navedo, Manuel F, Horne, Mary C, Hell, Johannes W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325713/
https://www.ncbi.nlm.nih.gov/pubmed/37338965
http://dx.doi.org/10.7554/eLife.79648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325713/
https://www.ncbi.nlm.nih.gov/pubmed/37338965
http://dx.doi.org/10.7554/eLife.79648

Ejemplares similares