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α(1)-Adrenergic receptor–PKC–Pyk2–Src signaling boosts L-type Ca(2+) channel Ca(V)1.2 activity and long-term potentiation in rodents

The cellular mechanisms mediating norepinephrine (NE) functions in brain to result in behaviors are unknown. We identified the L-type Ca(2+) channel (LTCC) Ca(V)1.2 as a principal target for G(q)-coupled α(1)-adrenergic receptors (ARs). α(1)AR signaling increased LTCC activity in hippocampal neurons...

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Detalles Bibliográficos
Autores principales:	Man, Kwun Nok Mimi, Bartels, Peter, Henderson, Peter B, Kim, Karam, Shi, Mei, Zhang, Mingxu, Ho, Sheng-Yang, Nieves-Cintron, Madeline, Navedo, Manuel F, Horne, Mary C, Hell, Johannes W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325713/ https://www.ncbi.nlm.nih.gov/pubmed/37338965 http://dx.doi.org/10.7554/eLife.79648

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