Epigenetic CpG duplex marks probed by an evolved DNA reader via a well-tempered conformational plasticity

5-methylcytosine (mC) and its TET-oxidized derivatives exist in CpG dyads of mammalian DNA and regulate cell fate, but how their individual combinations in the two strands of a CpG act as distinct regulatory signals is poorly understood. Readers that selectively recognize such novel ‘CpG duplex mark...

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Detalles Bibliográficos
Autores principales: Singh, Himanshu, Das, Chandan K, Buchmuller, Benjamin C, Schäfer, Lars V, Summerer, Daniel, Linser, Rasmus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325892/
https://www.ncbi.nlm.nih.gov/pubmed/36919612
http://dx.doi.org/10.1093/nar/gkad134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325892/
https://www.ncbi.nlm.nih.gov/pubmed/36919612
http://dx.doi.org/10.1093/nar/gkad134

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