Cargando…
Epigenetic CpG duplex marks probed by an evolved DNA reader via a well-tempered conformational plasticity
5-methylcytosine (mC) and its TET-oxidized derivatives exist in CpG dyads of mammalian DNA and regulate cell fate, but how their individual combinations in the two strands of a CpG act as distinct regulatory signals is poorly understood. Readers that selectively recognize such novel ‘CpG duplex mark...
Autores principales: | Singh, Himanshu, Das, Chandan K, Buchmuller, Benjamin C, Schäfer, Lars V, Summerer, Daniel, Linser, Rasmus |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325892/ https://www.ncbi.nlm.nih.gov/pubmed/36919612 http://dx.doi.org/10.1093/nar/gkad134 |
Ejemplares similares
-
Evolved
DNA Duplex Readers for Strand-Asymmetrically
Modified 5-Hydroxymethylcytosine/5-Methylcytosine CpG Dyads
por: Buchmuller, Benjamin C., et al.
Publicado: (2022) -
The Active Site of a Prototypical “Rigid” Drug Target is Marked by Extensive Conformational Dynamics
por: Singh, Himanshu, et al.
Publicado: (2020) -
Complete Profiling of Methyl-CpG-Binding Domains for Combinations of Cytosine Modifications at CpG Dinucleotides Reveals Differential Read-out in Normal and Rett-Associated States
por: Buchmuller, Benjamin C., et al.
Publicado: (2020) -
Recognition of methylated DNA through methyl-CpG binding domain proteins
por: Zou, Xueqing, et al.
Publicado: (2012) -
Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B
por: Lin, Chien-Chu, et al.
Publicado: (2020)