Abasic site–peptide cross-links are blocking lesions repaired by AP endonucleases

Apurinic/apyrimidinic (AP) sites are abundant DNA lesions arising from spontaneous hydrolysis of the N-glycosidic bond and as base excision repair (BER) intermediates. AP sites and their derivatives readily trap DNA-bound proteins, resulting in DNA–protein cross-links. Those are subject to proteolys...

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Detalles Bibliográficos
Autores principales: Yudkina, Anna V, Bulgakov, Nikita A, Kim, Daria V, Baranova, Svetlana V, Ishchenko, Alexander A, Saparbaev, Murat K, Koval, Vladimir V, Zharkov, Dmitry O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325907/
https://www.ncbi.nlm.nih.gov/pubmed/37216593
http://dx.doi.org/10.1093/nar/gkad423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325907/
https://www.ncbi.nlm.nih.gov/pubmed/37216593
http://dx.doi.org/10.1093/nar/gkad423

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