Identification of the SARS-unique domain of SARS-CoV-2 as an antiviral target

SARS-CoV-2 nsp3 is essential for viral replication and host responses. The SARS-unique domain (SUD) of nsp3 exerts its function through binding to viral and host proteins and RNAs. Herein, we show that SARS-CoV-2 SUD is highly flexible in solution. The intramolecular disulfide bond of SARS-CoV SUD i...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Bo, Li, Ziheng, Tang, Kaiming, Wang, Tongyun, Xie, Yubin, Aumonier, Sylvain, Wang, Meitian, Yuan, Shuofeng, Cui, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326071/
https://www.ncbi.nlm.nih.gov/pubmed/37414753
http://dx.doi.org/10.1038/s41467-023-39709-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326071/
https://www.ncbi.nlm.nih.gov/pubmed/37414753
http://dx.doi.org/10.1038/s41467-023-39709-6

Ejemplares similares