Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for the treatment of uranium-induced nephrotoxicity

Uranium (U) is a well-known nephrotoxicant which forms precipitates in the lysosomes of renal proximal tubular epithelial cells (PTECs) after U-exposure at a cytotoxic dose. However, the roles of lysosomes in U decorporation and detoxification remain to be elucidated. Mucolipin transient receptor po...

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Detalles Bibliográficos
Autores principales: Zhong, Dengqin, Wang, Ruiyun, Zhang, Hongjing, Wang, Mengmeng, Zhang, Xuxia, Chen, Honghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326073/
https://www.ncbi.nlm.nih.gov/pubmed/37414766
http://dx.doi.org/10.1038/s41467-023-39716-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326073/
https://www.ncbi.nlm.nih.gov/pubmed/37414766
http://dx.doi.org/10.1038/s41467-023-39716-7

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