Pyruvate transamination and NAD biosynthesis enable proliferation of succinate dehydrogenase-deficient cells by supporting aerobic glycolysis

Succinate dehydrogenase (SDH) is the mitochondrial enzyme converting succinate to fumarate in the tricarboxylic acid (TCA) cycle. SDH acts as a tumor suppressor with germline loss-of-function mutations in its encoding genes predisposing to aggressive familial neuroendocrine and renal cancer syndrome...

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Detalles Bibliográficos
Autores principales: Ricci, Luisa, Stanley, Federico Uchenna, Eberhart, Tanja, Mainini, Francesco, Sumpton, David, Cardaci, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326256/
https://www.ncbi.nlm.nih.gov/pubmed/37414778
http://dx.doi.org/10.1038/s41419-023-05927-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326256/
https://www.ncbi.nlm.nih.gov/pubmed/37414778
http://dx.doi.org/10.1038/s41419-023-05927-5

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