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Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations
Various c-mesenchymal-to-epithelial transition (c-MET) inhibitors are effective in the treatment of non-small cell lung cancer; however, the inevitable drug resistance remains a challenge, limiting their clinical efficacy. Therefore, novel strategies targeting c-MET are urgently required. Herein, th...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326257/ https://www.ncbi.nlm.nih.gov/pubmed/37425039 http://dx.doi.org/10.1016/j.apsb.2023.01.014 |