Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles

Indolylarylsulfones (IASs) are classical HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with a unique scaffold and possess potent antiviral activity. To address the high cytotoxicity and improve safety profiles of IASs, we introduced various sulfonamide groups linked by alkyl diamine...

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Detalles Bibliográficos
Autores principales: Gao, Shenghua, Song, Letian, Cheng, Yusen, Zhao, Fabao, Kang, Dongwei, Song, Shu, Yang, Mianling, Ye, Bing, Zhao, Wei, Tang, Yajie, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326263/
https://www.ncbi.nlm.nih.gov/pubmed/37425059
http://dx.doi.org/10.1016/j.apsb.2023.01.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326263/
https://www.ncbi.nlm.nih.gov/pubmed/37425059
http://dx.doi.org/10.1016/j.apsb.2023.01.003

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