Genetic fine-mapping from summary data using a nonlocal prior improves the detection of multiple causal variants

MOTIVATION: Genome-wide association studies (GWAS) have been successful in identifying genomic loci associated with complex traits. Genetic fine-mapping aims to detect independent causal variants from the GWAS-identified loci, adjusting for linkage disequilibrium patterns. RESULTS: We present “FiniM...

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Detalles Bibliográficos
Autores principales: Karhunen, Ville, Launonen, Ilkka, Järvelin, Marjo-Riitta, Sebert, Sylvain, Sillanpää, Mikko J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326304/
https://www.ncbi.nlm.nih.gov/pubmed/37348543
http://dx.doi.org/10.1093/bioinformatics/btad396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326304/
https://www.ncbi.nlm.nih.gov/pubmed/37348543
http://dx.doi.org/10.1093/bioinformatics/btad396

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