Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site

[Image: see text] The catalytic versatility of pentacoordinated iron is highlighted by the broad range of natural and engineered activities of heme enzymes such as cytochrome P450s, which position a porphyrin cofactor coordinating a central iron atom below an open substrate binding pocket. This cata...

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Detalles Bibliográficos
Autores principales: Kalvet, Indrek, Ortmayer, Mary, Zhao, Jingming, Crawshaw, Rebecca, Ennist, Nathan M., Levy, Colin, Roy, Anindya, Green, Anthony P., Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326885/
https://www.ncbi.nlm.nih.gov/pubmed/37341421
http://dx.doi.org/10.1021/jacs.3c02742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326885/
https://www.ncbi.nlm.nih.gov/pubmed/37341421
http://dx.doi.org/10.1021/jacs.3c02742

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