The interplay of DNA repair context with target sequence predictably biasses Cas9-generated mutations

The genome engineering capability of the CRISPR/Cas system depends on the DNA repair machinery to generate the final outcome. Several genes can have an impact on mutations created, but their exact function and contribution to the result of the repair are not completely characterised. This lack of kn...

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Detalles Bibliográficos
Autores principales: Pallaseni, Ananth, Peets, Elin Madli, Girling, Gareth, Crepaldi, Luca, Kuzmin, Ivan, Raudvere, Uku, Peterson, Hedi, Serçin, Özdemirhan, Mardin, Balca R., Kosicki, Michael, Parts, Leopold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326969/
https://www.ncbi.nlm.nih.gov/pubmed/37425722
http://dx.doi.org/10.1101/2023.06.28.546891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326969/
https://www.ncbi.nlm.nih.gov/pubmed/37425722
http://dx.doi.org/10.1101/2023.06.28.546891

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