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The interplay of DNA repair context with target sequence predictably biasses Cas9-generated mutations
The genome engineering capability of the CRISPR/Cas system depends on the DNA repair machinery to generate the final outcome. Several genes can have an impact on mutations created, but their exact function and contribution to the result of the repair are not completely characterised. This lack of kn...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326969/ https://www.ncbi.nlm.nih.gov/pubmed/37425722 http://dx.doi.org/10.1101/2023.06.28.546891 |