Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PINK1-deficient Human Dopamine Neurons

Mutations and loss of activity in the protein kinase PINK1 play a role in the pathogenesis of Parkinson’s disease (PD). PINK1 regulates many aspects of mitochondrial quality control including mitochondrial autophagy (mitophagy), fission, fusion, transport, and biogenesis. Defects in mitophagy are th...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Hu, Chen, Rong, Xiao, Liming, Kumar, Manoj, Acevedo-Cintrón, Jesús, Siuda, Joanna, Koziorowski, Dariusz, Wszolek, Zbigniew K., Dawson, Valina L., Dawson, Ted M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327008/
https://www.ncbi.nlm.nih.gov/pubmed/37425943
http://dx.doi.org/10.1101/2023.06.23.546087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327008/
https://www.ncbi.nlm.nih.gov/pubmed/37425943
http://dx.doi.org/10.1101/2023.06.23.546087

Ejemplares similares