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Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PINK1-deficient Human Dopamine Neurons

Mutations and loss of activity in the protein kinase PINK1 play a role in the pathogenesis of Parkinson’s disease (PD). PINK1 regulates many aspects of mitochondrial quality control including mitochondrial autophagy (mitophagy), fission, fusion, transport, and biogenesis. Defects in mitophagy are th...

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Detalles Bibliográficos
Autores principales:	Wang, Hu, Chen, Rong, Xiao, Liming, Kumar, Manoj, Acevedo-Cintrón, Jesús, Siuda, Joanna, Koziorowski, Dariusz, Wszolek, Zbigniew K., Dawson, Valina L., Dawson, Ted M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327008/ https://www.ncbi.nlm.nih.gov/pubmed/37425943 http://dx.doi.org/10.1101/2023.06.23.546087

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