SOS2 regulates the threshold of mutant EGFR-dependent oncogenesis

Son of Sevenless 1 and 2 (SOS1 and SOS2) are RAS guanine nucleotide exchange factors (RasGEFs) that mediate physiologic and pathologic RTK-dependent RAS activation. Here, we show that SOS2 modulates the threshold of epidermal growth factor receptor (EGFR) signaling to regulate the efficacy of and re...

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Detalles Bibliográficos
Autores principales: Theard, Patricia L., Linke, Amanda J., Sealover, Nancy E., Daley, Brianna R., Yang, Johnny, Cox, Katherine, Kortum, Robert L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327037/
https://www.ncbi.nlm.nih.gov/pubmed/37425733
http://dx.doi.org/10.1101/2023.01.20.524989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327037/
https://www.ncbi.nlm.nih.gov/pubmed/37425733
http://dx.doi.org/10.1101/2023.01.20.524989

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