Nuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation

Alterations of nuclear structure and function, and associated impact on gene transcription, are a hallmark of cancer cells. Little is known of these alterations in Cancer-Associated Fibroblasts (CAFs), a key component of the tumor stroma. Here we show that loss of androgen receptor (AR), which trigg...

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Detalles Bibliográficos
Autores principales: Ghosh, Soumitra, Isma, Jovan, Mazzeo, Luigi, Toniolo, Annagiada, Simon, Christian, Dotto, G. Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327063/
https://www.ncbi.nlm.nih.gov/pubmed/37425957
http://dx.doi.org/10.1101/2023.06.28.546870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327063/
https://www.ncbi.nlm.nih.gov/pubmed/37425957
http://dx.doi.org/10.1101/2023.06.28.546870

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