Two Classes of DNA Gyrase Inhibitors Elicit Distinct Evolutionary Trajectories Toward Resistance in Gram-Negative Pathogens

Comprehensive knowledge of mechanisms driving the acquisition of antimicrobial resistance is essential for the development of new drugs with minimized resistibility. To gain this knowledge, we combine experimental evolution in a continuous culturing device, the morbidostat, with whole genome sequenc...

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Detalles Bibliográficos
Autores principales: Leyn, Semen A., Kent, James E., Zlamal, Jaime E., Elane, Marinela L., Vercruysse, Maarten, Osterman, Andrei L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327078/
https://www.ncbi.nlm.nih.gov/pubmed/37425702
http://dx.doi.org/10.1101/2023.06.26.546596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327078/
https://www.ncbi.nlm.nih.gov/pubmed/37425702
http://dx.doi.org/10.1101/2023.06.26.546596

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