Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane Dynamics

Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTK) are important regulators of signaling in normal cells that can frequently be disrupted in cancer. The adrenal tumour pheochromocytoma (PCC) can be caused by activating mutations of the RET receptor ty...

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Detalles Bibliográficos
Autores principales: Walker, Timothy J., Reyes-Alvarez, Eduardo, Hyndman, Brandy D., Sugiyama, Michael G., Oliveira, Larissa C.B., Rekab, Aisha N., Crupi, Mathieu J.F., Cabral-Dias, Rebecca, Guo, Qianjin, Dahia, Patricia L.M., Richardson, Douglas S., Antonescu, Costin N., Mulligan, Lois M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327082/
https://www.ncbi.nlm.nih.gov/pubmed/37425958
http://dx.doi.org/10.1101/2023.06.28.546955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327082/
https://www.ncbi.nlm.nih.gov/pubmed/37425958
http://dx.doi.org/10.1101/2023.06.28.546955

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