A Bioluminescent Activity Dependent (BLADe) Platform for Converting Neuronal Activity to Photoreceptor Activation

We developed a platform that utilizes a calcium-dependent luciferase to convert neuronal activity into activation of light sensing domains within the same cell. The platform is based on a Gaussia luciferase variant with high light emission split by calmodulin-M13 sequences that depends on influx of...

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Detalles Bibliográficos
Autores principales: Crespo, Emmanuel L., Pal, Akash, Prakash, Mansi, Silvagnoli, Alexander D., Zaidi, Zohair, Gomez-Ramirez, Manuel, Tree, Maya O., Shaner, Nathan C., Lipscombe, Diane, Moore, Christopher, Hochgeschwender, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327117/
https://www.ncbi.nlm.nih.gov/pubmed/37425742
http://dx.doi.org/10.1101/2023.06.25.546469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327117/
https://www.ncbi.nlm.nih.gov/pubmed/37425742
http://dx.doi.org/10.1101/2023.06.25.546469

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