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Identification of small molecule inhibitors of G3BP-driven stress granule formation

Stress granule formation is triggered by the release of mRNAs from polysomes and is promoted by the action of the paralogs G3BP1 and G3BP2. G3BP1/2 proteins bind mRNAs and thereby promote the condensation of mRNPs into stress granules. Stress granules have been implicated in several disease states,...

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Detalles Bibliográficos
Autores principales: Freibaum, Brian D., Messing, James, Nakamura, Haruko, Yurtsever, Ugur, Wu, Jinjun, Kim, Hong Joo, Hixon, Jeff, Lemieux, Rene, Duffner, Jay, Huynh, Walter, Wong, Kathy, White, Michael, Lee, Christia, Meyers, Rachel, Parker, Roy, Taylor, J. Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327151/
https://www.ncbi.nlm.nih.gov/pubmed/37425931
http://dx.doi.org/10.1101/2023.06.27.546770