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HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide

BACKGROUND: The origin and genesis of highly malignant and heterogenous glioblastoma brain tumors remain unknown. We previously identified an enhancer-associated long non-coding RNA, LINC01116 (named HOXDeRNA here), that is absent in the normal brain but is commonly expressed in malignant glioma. HO...

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Detalles Bibliográficos
Autores principales: Deforzh, Evgeny, Kharel, Prakash, Karelin, Anton, Ivanov, Pavel, Krichevsky, Anna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327164/
https://www.ncbi.nlm.nih.gov/pubmed/37425921
http://dx.doi.org/10.1101/2023.06.30.547275