SR-TWAS: Leveraging Multiple Reference Panels to Improve TWAS Power by Ensemble Machine Learning

Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for TWAS. To leverage expression imputation models (i.e., base models) trained with multiple reference panels, regression methods,...

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Detalles Bibliográficos
Autores principales: Parrish, Randy L., Buchman, Aron S., Tasaki, Shinya, Wang, Yanling, Avey, Denis, Xu, Jishu, De Jager, Philip L., Bennett, David A., Epstein, Michael P., Yang, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327185/
https://www.ncbi.nlm.nih.gov/pubmed/37425698
http://dx.doi.org/10.1101/2023.06.20.23291605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327185/
https://www.ncbi.nlm.nih.gov/pubmed/37425698
http://dx.doi.org/10.1101/2023.06.20.23291605

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