Uncovering Protein Ensembles: Automated Multiconformer Model Building for X-ray Crystallography and Cryo-EM

With the advent of AlphaFold, protein structure prediction has attained remarkable accuracy. These achievements resulted from a focus on single static structures. The next frontier in this field involves enhancing our ability to model conformational ensembles, not just the ground states of proteins....

Descripción completa

Detalles Bibliográficos
Autores principales: Wankowicz, Stephanie A., Ravikumar, Ashraya, Sharma, Shivani, Riley, Blake T., Raju, Akshay, Hogan, Daniel W., van den Bedem, Henry, Keedy, Daniel A., Fraser, James S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327213/
https://www.ncbi.nlm.nih.gov/pubmed/37425870
http://dx.doi.org/10.1101/2023.06.28.546963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327213/
https://www.ncbi.nlm.nih.gov/pubmed/37425870
http://dx.doi.org/10.1101/2023.06.28.546963

Ejemplares similares