Uncovering Protein Ensembles: Automated Multiconformer Model Building for X-ray Crystallography and Cryo-EM

With the advent of AlphaFold, protein structure prediction has attained remarkable accuracy. These achievements resulted from a focus on single static structures. The next frontier in this field involves enhancing our ability to model conformational ensembles, not just the ground states of proteins....

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Detalles Bibliográficos
Autores principales: Wankowicz, Stephanie A., Ravikumar, Ashraya, Sharma, Shivani, Riley, Blake T., Raju, Akshay, Hogan, Daniel W., van den Bedem, Henry, Keedy, Daniel A., Fraser, James S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327213/
https://www.ncbi.nlm.nih.gov/pubmed/37425870
http://dx.doi.org/10.1101/2023.06.28.546963

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