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A note on p-value multiple-testing adjustment for two-step genome-wide gene-environment interactions scans

Two-step testing is the state-of-the art approach for performing genome-wide interaction scans (GWIS). It is computationally efficient and yields higher power than standard single-step-based GWIS for virtually all biologically plausible scenarios. However, while two-step tests control the genome-wid...

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Detalles Bibliográficos
Autores principales: Lewinger, Juan Pablo, Kawaguchi, Eric S., Gauderman, W. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327251/
https://www.ncbi.nlm.nih.gov/pubmed/37425767
http://dx.doi.org/10.1101/2023.06.27.23291946