Cargando…

Differential DNA Methylation in the Brain as Potential Mediator of the Association between Traffic-related PM(2.5) and Neuropathology Markers of Alzheimer’s Disease

INTRODUCTION: Growing evidence indicates fine particulate matter (PM(2.5)) as risk factor for Alzheimer’s’ disease (AD), but the underlying mechanisms have been insufficiently investigated. We hypothesized differential DNA methylation (DNAm) in brain tissue as potential mediator of this association....

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zhenjiang, Liang, Donghai, Ebelt, Stefanie, Gearing, Marla, Kobor, Michael S., Konwar, Chaini, Maclsaac, Julie L, Dever, Kristy, Wingo, Aliza, Levey, Allan, Lah, James J., Wingo, Thomas, Huels, Anke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327281/ https://www.ncbi.nlm.nih.gov/pubmed/37425713 http://dx.doi.org/10.1101/2023.06.30.23292085

Ejemplares similares

Fine particulate air pollution and neuropathology markers of Alzheimer’s disease in donors with and without APOE ε4 alleles – results from an autopsy cohort
por: Christensen, Grace M., et al.
Publicado: (2023)

LDL cholesterol is associated with higher AD neuropathology burden independent of APOE
por: Wingo, Aliza P, et al.
Publicado: (2022)

Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease
por: Dai, Jingting, et al.
Publicado: (2018)

Brain microRNAs are associated with variation in cognitive trajectory in advanced age
por: Wingo, Aliza P., et al.
Publicado: (2022)

An integrative framework and recommendations for the study of DNA methylation in the context of race and ethnicity
por: Chan, Meingold Hiu-ming, et al.
Publicado: (2023)

Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level
por: Johnson, Erik C. B., et al.
Publicado: (2022)

Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age
por: Wingo, Aliza P., et al.
Publicado: (2019)

Shared mechanisms across the major psychiatric and neurodegenerative diseases
por: Wingo, Thomas S., et al.
Publicado: (2022)

Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
por: Ping, Lingyan, et al.
Publicado: (2018)

Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia
por: Wingo, Thomas S., et al.
Publicado: (2020)

Association between DNA methylation levels in brain tissue and late-life depression in community-based participants
por: Hüls, Anke, et al.
Publicado: (2020)

Identifying latent genetic interactions in genome-wide association studies using multiple traits
por: Bass, Andrew J., et al.
Publicado: (2023)

Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain
por: Wingo, Aliza P., et al.
Publicado: (2020)

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis
por: Wingo, Aliza P., et al.
Publicado: (2021)

Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer’s disease
por: Ping, Lingyan, et al.
Publicado: (2020)

The complex relationship of air pollution and neighborhood socioeconomic status and their association with cognitive decline
por: Christensen, Grace M., et al.
Publicado: (2022)

A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with NTNG1 and CNOT3
por: Vattathil, Selina M., et al.
Publicado: (2021)

Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer’s Disease
por: Guo, Qi, et al.
Publicado: (2021)

Brain proteome-wide association study implicates novel proteins in depression pathogenesis
por: Wingo, Thomas S., et al.
Publicado: (2021)

Predictors of Cognitive Decline in Healthy Middle-Aged Individuals with Asymptomatic Alzheimer’s Disease
por: Tandon, Raghav, et al.
Publicado: (2023)

Proteomic Network Analysis of Alzheimer’s Disease Cerebrospinal Fluid Reveals Alterations Associated with APOE ε4 Genotype and Atomoxetine Treatment
por: Dammer, Eric B., et al.
Publicado: (2023)

Sex differences in brain protein expression and disease
por: Wingo, Aliza P., et al.
Publicado: (2023)

Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorder
por: Wingo, Thomas S., et al.
Publicado: (2022)

Proteomic Analysis of Hippocampal Dentate Granule Cells in Frontotemporal Lobar Degeneration: Application of Laser Capture Technology
por: Gozal, Yair M., et al.
Publicado: (2011)

A proteomic network approach across the ALS‐FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain
por: Umoh, Mfon E, et al.
Publicado: (2017)

Lowering hippocampal miR-29a expression slows cognitive decline and reduces beta-amyloid deposition in 5xFAD mice
por: Mei, Zhen, et al.
Publicado: (2023)

Autosomal sex-associated co-methylated regions predict biological sex from DNA methylation
por: Gatev, Evan, et al.
Publicado: (2021)

Transporte y suelo urbano
por: Wingo, Lowdon
Publicado: (1972)

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production
por: Herskowitz, Jeremy H., et al.
Publicado: (2012)

U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21
por: Hales, Chadwick M, et al.
Publicado: (2014)

Family environment and adult resilience: contributions of positive parenting and the oxytocin receptor gene
por: Bradley, Bekh, et al.
Publicado: (2013)

TBK1 interacts with tau and enhances neurodegeneration in tauopathy
por: Abreha, Measho H., et al.
Publicado: (2021)

Association of a placental Interleukin-6 genetic variant (rs1800796) with DNA methylation, gene expression and risk of acute chorioamnionitis
por: Konwar, Chaini, et al.
Publicado: (2019)

Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer’s disease
por: Gockley, Jake, et al.
Publicado: (2021)

Alkaline activation of ClC-K2 chloride channels switches renal cells from reabsorbing to secreting
por: Wingo, Charles S., et al.
Publicado: (2016)

CSF complement 3 and factor H are staging biomarkers in Alzheimer’s disease
por: Hu, William T., et al.
Publicado: (2016)

Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs
por: Wingo, Aliza P., et al.
Publicado: (2016)

MicroRNA-650 Regulates the Pathogenesis of Alzheimer’s Disease Through Targeting Cyclin-Dependent Kinase 5
por: Lin, Li, et al.
Publicado: (2023)

Mitochondrial respiratory chain protein co-regulation in the human brain
por: Trumpff, Caroline, et al.
Publicado: (2022)

Risk-focused differences in molecular processes implicated in SARS-CoV-2 infection: corollaries in DNA methylation and gene expression
por: Konwar, Chaini, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_k8fq678v0l85kq8nki9cs7nt1i