Cargando…

Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments

Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune system's T-cells to recognize and attack tumor cells. T-cells are isolated from patients and modified to target tumo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dagar, Gunjan, Gupta, Ashna, Masoodi, Tariq, Nisar, Sabah, Merhi, Maysaloun, Hashem, Sheema, Chauhan, Ravi, Dagar, Manisha, Mirza, Sameer, Bagga, Puneet, Kumar, Rakesh, Akil, Ammira S. Al-Shabeeb, Macha, Muzafar A., Haris, Mohammad, Uddin, Shahab, Singh, Mayank, Bhat, Ajaz A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327392/ https://www.ncbi.nlm.nih.gov/pubmed/37420216 http://dx.doi.org/10.1186/s12967-023-04292-3

Ejemplares similares

Correction: Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments
por: Dagar, Gunjan, et al.
Publicado: (2023)

Integration of CRISPR/Cas9 with artificial intelligence for improved cancer therapeutics
por: Bhat, Ajaz A., et al.
Publicado: (2022)

Epigenetic modifications: Key players in cancer heterogeneity and drug resistance
por: Sadida, Hana Q., et al.
Publicado: (2023)

Non-invasive biomarkers for monitoring the immunotherapeutic response to cancer
por: Nisar, Sabah, et al.
Publicado: (2020)

Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression
por: Chauhan, Ravi, et al.
Publicado: (2023)

Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
por: Chauhan, Ravi, et al.
Publicado: (2021)

Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy
por: Bhat, Ajaz A., et al.
Publicado: (2022)

Chemokine-Cytokine Networks in the Head and Neck Tumor Microenvironment
por: Nisar, Sabah, et al.
Publicado: (2021)

Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments
por: Lone, Saife N., et al.
Publicado: (2022)

Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies
por: Nisar, Sabah, et al.
Publicado: (2021)

Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis
por: Sharma, Tarang, et al.
Publicado: (2022)

Association of genes with phenotype in autism spectrum disorder
por: Nisar, Sabah, et al.
Publicado: (2019)

Genetics of glutamate and its receptors in autism spectrum disorder
por: Nisar, Sabah, et al.
Publicado: (2022)

The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile
por: Fatima, Munazza Tamkeen, et al.
Publicado: (2022)

Claudin-1, A Double-Edged Sword in Cancer
por: Bhat, Ajaz A., et al.
Publicado: (2020)

Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder
por: Nisar, Sabah, et al.
Publicado: (2020)

Genetics of structural and functional brain changes in autism spectrum disorder
por: Hashem, Sheema, et al.
Publicado: (2020)

Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway
por: Akhtar, Sabah, et al.
Publicado: (2022)

Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India
por: Bhat, Gh. Rasool, et al.
Publicado: (2023)

Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
por: Bhat, Ajaz A., et al.
Publicado: (2021)

CAR-T-Cell Therapy in Multiple Myeloma: B-Cell Maturation Antigen (BCMA) and Beyond
por: Mishra, Abhinava K., et al.
Publicado: (2023)

The link between glycemic control measures and eye microvascular complications in a clinical cohort of type 2 diabetes with microRNA-223-3p signature
por: Da’as, Sahar I., et al.
Publicado: (2023)

Long non-coding RNAs modulate tumor microenvironment to promote metastasis: novel avenue for therapeutic intervention
por: Baba, Sana Khurshid, et al.
Publicado: (2023)

Activation of GPR56, a novel adhesion GPCR, is necessary for nuclear androgen receptor signaling in prostate cells
por: Singh, Julie Pratibha, et al.
Publicado: (2020)

Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder
por: Yadav, Santosh K., et al.
Publicado: (2021)

Network-based identification and prioritization of key transcriptional factors of diabetic kidney disease
por: Ahmed, Ikhlak, et al.
Publicado: (2023)

Role of NAD(+) in regulating cellular and metabolic signaling pathways
por: Amjad, Sara, et al.
Publicado: (2021)

Molecular Analysis and Conformational Dynamics of Human MC4R Disease-Causing Mutations
por: Fatima, Munazza Tamkeen, et al.
Publicado: (2022)

Melanocortin‐4 receptor complexity in energy homeostasis,obesity and drug development strategies
por: Fatima, Munazza Tamkeen, et al.
Publicado: (2022)

Brain microstructural changes support cognitive deficits in HIV uninfected children born to HIV infected mothers
por: Yadav, Santosh K., et al.
Publicado: (2020)

Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era
por: Akil, Ammira Al-Shabeeb, et al.
Publicado: (2021)

Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk
por: Bhat, Ajaz A., et al.
Publicado: (2019)

Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes
por: Akil, Ammira-Sarah AL-Shabeeb, et al.
Publicado: (2020)

Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity
por: Relecom, Allan, et al.
Publicado: (2021)

Editorial: Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer
por: Dermime, Said, et al.
Publicado: (2021)

Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy
por: Raza, Afsheen, et al.
Publicado: (2020)

A de novo start-loss in EFTUD2 associated with mandibulofacial dysostosis with microcephaly: case report
por: Kohailan, Muhammad, et al.
Publicado: (2022)

Dataset on fabrication of an improved L-lactate biosensor based on lactate oxidase/cMWCNT/CuNPs/PANI modified PG electrode
por: Dagar, Kusum, et al.
Publicado: (2018)

Differential Properties of the Synaptogenic Activities of the Neurexin Ligands Neuroligin1 and LRRTM2
por: Dagar, Sushma, et al.
Publicado: (2019)

Incidental floating aortic thrombus in severe pulmonary COVID-19 infection
por: Dagar, Saloni, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q56jahanh7fbal12joo7pvu0ed