A Novel Inhibitor of DKK1/LRP6 Interactions Against the Alzheimer Disease: An Insilco Approach

The activation of the Wnt signaling pathway is implicated in a neuroprotective mechanism against the Alzheimer disease. When this pathway is blocked, it activates GSK3 beta, leading to tau hyperphosphorylation and the apoptosis of neurons. Dickkopf-related protein 1 (DKK1) is a protein that competes...

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Detalles Bibliográficos
Autores principales: Prajapat, Manisha, Singh, Harvinder, Chaudhary, Gajendra, Sarma, Phulen, Kaur, Gurjeet, Prakash Patel, Ajay, Medhi, Bikash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328054/
https://www.ncbi.nlm.nih.gov/pubmed/37424708
http://dx.doi.org/10.1177/11779322231183762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328054/
https://www.ncbi.nlm.nih.gov/pubmed/37424708
http://dx.doi.org/10.1177/11779322231183762

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