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Explainable multi-task learning improves the parallel estimation of polygenic risk scores for many diseases through shared genetic basis
Many complex diseases share common genetic determinants and are comorbid in a population. We hypothesized that the co-occurrences of diseases and their overlapping genetic etiology can be exploited to simultaneously improve multiple diseases’ polygenic risk scores (PRS). This hypothesis was tested u...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328362/ https://www.ncbi.nlm.nih.gov/pubmed/37418352 http://dx.doi.org/10.1371/journal.pcbi.1011211 |